The Complete Fourth Season was released onto DVD in region one on October 10, 2006. It contains all 25 Season Four episodes, plus bonus features.
- This year, the laughs are off the charts in TV's most surreal and sidesplitting show. Scrubs’ hilarious fourth season does "an amazing job combining cheeky comedy... and honestly poignant drama," raves Newsweek.
- Catch the most contagious comedy around with every episode, complete with hysterical bonus features and the show's original, unedited music in 5.1 Surround Sound.
- Matthew Perry, Tom Cavanagh, and Molly Shannon are just a few of the guest stars joining the staff this year. And the crew of Sacred Heart makes their biggest moves yet as Elliot leaves the hospital for a new job, and J.D. faces life on his own for the first time.
DVD case description
The Fourth Season DVD case is once again all cardboard. The sleeve and fold-out case have promotional images of the cast and from episodes. The discs have images of skeletons on them, and discs 1 and 2 line up to make a bigger skeleton.
- "My Old Friend's New Friend" **
- "My Office"
- "My New Game"
- "My First Kill"
- "Her Story"
- "My Cake"
- "My Common Enemy"
- "My Last Chance" *
- "My Malpractical Decision"
- "My Female Trouble"
- "My Unicorn"
- "My Best Moment"
- "My Ocardial Infarction"
- "My Lucky Charm"
- "My Hypocritical Oath"
- "My Quarantine"
- "My Life in Four Cameras" *
- "My Roommates"
- "My Best Laid Plans"
- "My Boss's Free Haircut"
- "My Lips Are Sealed"
- "My Big Move"
- "My Faith in Humanity"
- "My Drive-By"
- "My Changing Ways"
- Bonus Features
- * Optional audio commentary.
- ** Supersized episode.
- Will You Ever Be My Mentor? — A hilarious look at J.D.'s never-ending quest for Dr. Cox's approval
- The Sweethearts Of Sacred Heart — In-depth interviews about the romantic entanglements and flirtations of the Scrubs characters
- Secondary Characters — Get to know the secondary cast members and their roles
- Who's That Man? — A look at the mysterious character The Janitor
- Scrubbed Out - Deleted Scenes
- Donald Keeps Talking - An extended sit-down interview with actor Donald Faison
- The Weapons Chest - Spend some time with the show's "second squad" of actors
- Alternate lines: A Second Opinion
- Music video by G Tom Mac: "Half"
- Audio Commentaries on two episodes
- One "Supersized" episode (approximately 3 minutes longer than originally aired)
- "My Old Friend's New Friend" (24:35)
The menus are once again CGI areas of Sacred Heart. This season, the cafeteria is featured. Different videos of the episodes are played as if they were dished of food.