Kelli was born in Los Angeles, California. She had appeared in numerous TV programs including Law & Order, Quantum Leap, and Ally McBeal. She held a recurring role in The Practice where she appeared in 138 episodes. She received several Screen Actors Guild Award nominations. She also had a starring role in the short-lived Medical Investigation and has most recently appeared in many episodes of Men in Trees. Kelli is currently starring in the Fox series Lie to Me.